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"Event related potential (ERP) methodology provides a measure of brain electrical activity in response to an experimental stimulus. The P300, an endogenous component of the ERP, is associated with cognitive activity and is purported to reflect stimulus recognition and information processing. Previous results from our lab suggest that alexithymic individuals, those who are unable to identify and label their own emotional state, show reduced early cognitive processing of affectively neutral auditory stimuli in the frontal regions of the brain. Based on the premise that ALEXITHYMIA could be the result of an increased left hemisphere activation or reduced activation of the right hemisphere it was expected that the P300 amplitude of the left hemisphere would be greater than that of the right hemisphere. Specifically, the left frontal P300 amplitude was expected to be greater than the central and posterior P300 amplitudes of the left hemisphere; as the discrepant activity in the prefrontal cortex and the anterior cingulate cortex (ACC) has been found in patients with alexithymia. In the present study, alexithymia correlated with the P300 amplitude. However, results varied for each hypothesis by TAS-20 factor scores and not the TAS-20 total score. Future studies focusing on the specific factors that comprise the multifaceted construct of alexithymia (e.g., as measured by the TAS-20) may provide more insight into the dimension of emotion and braiN/behavior relationships."
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