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Notes
- Abstract:
- It has been noted in the research literature that there is no systematic difference in affinity of monoclonal antibodies raised against the native glycoprotein (MabW) as compared to monoclonal antibodies raised against the aglyconic tandem polypeptide of the core protein (MabT) for the native glycosylated epithelial mucin 1. However, there is no research in the literature comparing the affinity of these two monoclonal antibodies for the aglyconic epithelial mucin 1 core protein. This project investigated the affinity of MabW and MabT for the aglyconic epithelial mucin 1 core protein in an atypical case of extramammary Paget’s disease. The limiting dilution was used and results were analyzed using the Kolmogorov- Smirnov two sample test with an alpha of 0.05. There was no systematic difference in the affinity for the aglyconic epithelial mucin 1 between MabW and MabT. This suggests that the numerous oligosaccharide side chains of the human epithelial mucin 1 have little to do with antigenicity. ( , )
- Subject:
- Extramammary Paget's Disease (EMPD). Adenocarcinoma. Neoplastic cells.
- Thesis:
- Thesis (M.S.)--Barry University, 2008.
- Bibliography:
- Includes bibliographical references (leaves 49-56).
Record Information
- Source Institution:
- Barry University
- Holding Location:
- Barry University Archives and Special Collections
- Rights Management:
- Copyright Shakira L. I. Henderson. Permission granted to Barry University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
- Resource Identifier:
- QM491.H46 2008_HendersonShakira ( BU-Local )
- Classification:
- QM491.H46 2008 ( lcc )
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