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|a SF762.A55 2009_AlkhenaiziKadhem |2 BU-Local |
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|a Effects of denervation on fast-twitch extensor digitorium longus and slow-twitch soleus muscles of the rat |h [electronic resource]. |
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|a Miami, Fla. : |b Barry University, |c 2009. |
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|a vii, 74 leaves : |b ill., photographs : 28 cm |
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|a Barry University Theses -- School of Podiatric Medicine. |
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|a Thesis (M.S.)--Barry University, 2009. |
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|a Includes bibliographical references (leaves 71-74). |
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|a Copyright Kadhem Alkhenaizi. Permission granted to Barry University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder. |
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|a This study is set out to examine the response of two different muscles to loss of innervations. Serial frozen sections (10 pm thick) of fast-twitch extensor digitorium longus muscles (EDL) and slow-twitch soleus muscles (SOL.) of the denervated and contralateral control hindlimbs at different time points (one, two and three weeks) were compared using different enzyme histochemical and immunohistochemical techniques. It was hypothesized that the fiber types in the two muscles would respond similarly to the loss of neuronal influence. Succinate dehydrogenase (SDH) was used to determine the oxidative capacity, while phosphorylase (PURL) was used to determine the glycolytic capacity. The expression of myosin heavy chain (Ml (MHC) isoforms were determined by immunohistochemistry. Based on the enzyme histochemical and immunohistochemical reactions, type 1 and 2A fibers in the denervated SOL showed severe progressive atrophy with time relative to the contralateral control SOL. Different fibers in the denervated EDL showed different extents of atrophy with time, type 2B fibers atrophied the most, then type 2X fibers and type 2A atrophied to a lesser extent relative to the contralateral control EDL. In addition, type 2B, 2X, and 2A fibers showed decreased glycolytic activities with time. In contrast, denervated type 1 fibers of the EDL maintained their size during the three week of denervation and expressed glycolytic activities. Thus, the results of the study showed that the fast-twitch EDL and slow-twitch SOL muscles responded differently to the loss innervation. |
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|a Electronic reproduction. |c Barry University, |d 2020. |f (Barry University Digital Collections) |n Mode of access: World Wide Web. |n System requirements: Internet connectivity; Web browser software. |
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|a Barry University Archives and Special Collections. |
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|a Musculoskeletal system. |
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|a Animal experimentation. |
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|a Barry University Digital Collections. |
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|a Theses and Dissertations. |
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|a BUDC |c Theses and Dissertations |
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|u http://sobekcmsrv.barrynet.barry.edu/AA00001950/00001 |y Click here for full text |
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|a https:/budc.barry.edu/content/AA/00/00/19/50/00001/SF762_A55 2009_AlkhenaiziKadhemthm.jpg |
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|a Theses and Dissertations |
